Iodine pentafluoride is used as a fluorinating agent in organic synthesis.

The main application is in telomerization processes, where IF5 is reacted with tetrafluoroethylene to produce fluorinated alkyl iodide with linear, even numbered alkyl chain lengths, so called fluorotelomer.

Iodine pentafluoride is a colorless liquid with a pungent odor. The highly reactive IF5 (melting point 9.4 °C) is distillable at 100.5 °C without any decomposition. Decomposition commences at temperatures above 400 °C.