Triflic anhydride may be used to introduce a protective trifluoromethane sulfonyl group. It is a strong activator of hydroxyl groups, for example in glycosidation reactions. It is an efficient promoter for inversion configuration and for nucleophilic substitutions. It may also be used as an activator of phenols or enols for the synthesis of aryl and vinyl triflates.


  • CAS number
  • Global Business Unit
    Special Chem
  • Synonyms
    Trifluoromethanesulfonic anhydride; TAA


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Chemical categories

Chemical category Chemical family Chemical product
Fluorine derivatives Fluorinated Chemicals Triflic acid anhydride

Region of commercial availability

  • Asia / Pacific
  • Europe / Middle East / Africa
  • North America
  • Latin America

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